Jeff is Director of the Vanderbilt Center for Immunobiology and co-leader of the Molecular Pathology and Immunology PhD training program at Vanderbilt University School of Medicine. Jeff studies metabolic mechanisms that control inflammatory diseases and cancer, with a particular focus on how nutrient uptake and cell signaling cues are integrated to influence lymphocyte function and fate.
Following undergraduate studies in Biology at the University of Northern Iowa, Jeff earned a PhD in Immunology on B cell tolerance and death mechanisms at Stanford University. He completed postdoctoral studies at the University of Chicago and the University of Pennsylvania showing that the metabolism of lymphocytes was dynamically regulated to control lymphocyte function and survival.
Selected Publications
- Metabolic barriers to T cell function in tumors. Journal of Immunology (2018), 200(2), 400-407.
- Similarities and distinctions of cancer and immune metabolism in inflammation and tumors. Cell Metabolism (2017), 26(1), 49-70.
- Fine tuning of immunometabolism for the treatment of rheumatic diseases. Nature Reviews Rheumatology (2017), 13(5), 313-320.
- Foxp3 and toll-like receptor signaling balance Treg cell anabolic metabolism for suppression. Nature Immunology (2016), 17(12), 1459-1466.
- A guide to immunometabolism for immunologists. Nature Reviews Immunology (2016), 16(9), 553-565.
